a Record control number 000261489200009

a ISSN 0362-5664

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QV4

b Item number .R48 2008

a Personal name Mut, Senem E.

h Medium Electronic Document

a Title Reversible Encephalopathy Due to Sulfasalazine.

c Statement of responsibility, etc Senem E. Mut, Gulnihal Kutlu, Serap Ucler, Abidin Erdal, Levent E. Inan.

a Place of publication, distribution, etc Lippincott Williams & Wilkins,

c Date of publication, distribution, etc 2008.

a Summary, etc Background: Sulfasalazine was devised by Swedish physician in the late 1930s in an attempt to treat "rheumatic polyarthritis." It is still a widely used anti-inflammatory agent especially in the treatment of rheumatologic disorders and inflamatory bowel diseases. Most of its side effects are benign, tolerable, and dose dependent, but less common severe systemic reactions have also been revealed. Case Presentation: A 42-year-old woman diagnosed with rheumatoid arthritis was admitted to emergency service because of status epilepticus. Hepatitis and myelotoxicity were also present after laboratory investigations. The patient was on sulfasalazine treatment for 3 weeks with a daily dose of 2g. Cranial magnetic resonance imaging (MRI) revealed bilateral petiventricular and subcortical lesions in the white matter of especially temporal and occipital regions. Cerebrospinal fluid (CSF) examination showed very high protein level (564 mg/L). After discontinuation of treatment, the clinical, CSF, and MRI findings regressed rapidly Conclusions: Side effects of sulfasalazine include neurotoxicity such as status epilepticus, cranial MRI lesions, and CSF abnormalities that were diagnosed in our patient after excluding other etiologic factors causing encephalitis.

a Topical term or geographic name as entry element Clinical Neurology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Pharmacology

a Main entry heading Clinical Neuropharmacology

g Relationship information NOV-DEC 2008, Vol 31 Issue 6, p368-371

x International Standard Serial Number 03625664

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1097/WNF.0B013E31817F125D